Photo from The Guardian |
Blogger's Notes:
Commentary of an Academic
(Copyright @ 2020 by Chester B Cabalza. All Rights Reserved).
Caveat! Just like in Part 1, the fiction comes from the figment of my imagination. The story takes off after the professor gathers his gang as they unlock mysteries behind the making of vaccines. Calling the
shots of Resistance, the brilliant Sergio Marquina sends them off to major global
cities to find the cure and halt the coronavirus pandemic as the WHO launched
the coordinated “Solidarity Trial” in 10 countries around five continents.
Part 2
(Outdoor) Across the
vastness of the South China Sea, Tokyo and Lisbon scuba dive like mermaids in
full battle gear. They survive the marine extremes beneath the ocean. Crossing
the threshold of Liaoning’s hull, China’s largest combat aircraft battleship
and symbol of naval dominance in the world’s busiest sea lane.
From
the weather deck bossing the ship’s forecastle, birds hurl quickly in remote
air; gracefully it flap wings to the horizon. The king sun makes way for its
dramatic exit in a grotesque sunset shimmer as the warship wallops the salty body
of water and keeps buoyancy in the deep blue sea.
Tokyo
carefully throws the antiretroviral drug to Lisbon (a survivor of the COVID
disease herself in Madrid).
Tokyo:
Inject it in your body! (She whispers to her. Lisbon keeps mum and paranoid).
They
run and hide near the aircraft carriers. Sailors from the People’s Liberation
Army Navy deploy a drone and force feed radio frequency identification around
the missiles.
A
Chengdu J-20 Chinese fighter jet deplanes. Gandia arrives in full personal protective
equipment (PPE) in red jumpsuit wearing a realistic Salvador Dali mask,
accompanied by three biogenetically cyborg assassins, chemically brainwashed, and
genetically immune by a tailored virus. Cyborg assassins can’t be infected by
the coronavirus.
Professor:
Don’t you shoot Gandia! He’s on our side! (Talking to the combative ladies
using satellite phone patch from his distant hollow).
Lisbon:
Sergio, how can we trust him? (Worried of treachery).
Professor:
Just trust me! (he sighs in deep breath). Bogota and Denver injected convalescent
plasma to Gandia after you recovered from COVID. Your blood contains antibodies
to fight the virus. Antibodies are found in the plasma.
Tokyo:
Very well! How sure are you that your woman Lisbon is safe here? Are we safe
here? I’m used to bank robberies and battles, eh! But not like this one. The
virus is unseen, professor! (her temperament explodes like the intensity and
stealth of a cat fighter).
You
told us what happened in the USS Roosevelt; almost all of the American sailors
were asymptomatically infected by the virus! It’s contagious! What shall we do
now? Did they find a vaccine yet in Washington?
Lisbon:
Gandia can get exposed again to the virus, even if we both recovered from COVID
(voice cracking).
Professor:
Listen (he tries to calm the two). China solely manufactures Carrimycin tablets, a possible cure for
COVID-19-2020.
But
Gandia will take the clinical trials for favipivar.
Billions of doses are now mass-produced in Wuhan and Shenzhen, after the drug
had undergone clinical trials.
Come
to think of it ladies, there are 58 candidate drugs for antibodies, 22 for antivirals,
14 for cell-based compound, five for RNA-based compounds, 15 for scanning
compounds to be repurposed, and various other therapy categories for
anti-inflammatory, antimalarial, interferon, protein-based, antibiotics, and
receptor-modulating compounds.
How can you not take the chances if there are other 66 candidate drugs? Imagine all the 249 compounds our scientists and military physicians are doing today. The world is developing 115 vaccine candidates; let’s not lose this momentum, ladies.
How can you not take the chances if there are other 66 candidate drugs? Imagine all the 249 compounds our scientists and military physicians are doing today. The world is developing 115 vaccine candidates; let’s not lose this momentum, ladies.
Don’t
leave Gandia inside the Liaoning! That’s the safest passage to reach Shanghai
and Beijing because of the lockdown! Medicines are needed
to be shipped across the world. Make sure that the warship carrier is safe and
gets the right of passage once you reach the Horn of Africa and Panama Canal.
Tokyo:
Where are the other members of the team?
Professor:
I sent them to biotechnology firms and universities. Manila and Denver are in
India. Helsinki and Palermo went to Germany. Rio just reached
Italy while Stockholm has seen the mass grave in Brazil. Arturo talked to the CIA in New York while Marcella is talking to
Jacinda Ardern in New Zealand.
Tokyo: Make sure we’re all safe, professor! I hope no one from the team will die this time!
(Staring at Lisbon, agitated and sharp).
Professor:
(Listening in silence. Deep thinking. Mind wanders. Afraid...so afraid)
***
(Indoor) The gang seriously
listens to the professor as he vividly lectures on smallpox vaccine discovered
by British physician Dr. Edward Jenner.
In
the flashback, all of the dead characters are alive sharing their thoughts with
robber colleagues (Oslo, Berlin, Moscow, and Nairobi are seated while observing
physical distancing inside the chamber).
Berlin
walks beside the professor and starts discussing about immunization.
Berlin:
(always candid and charismatic especially when he sneers to the team). Dr.
Jenner’s work is considered as the foundation of immunology (showing his old
photo from the screen). His vaccine killed the smallpox, the only infectious
disease to have naturally been eradicated in human history.
Professor: But evil nations will always use infectious
diseases for its advantage as a bioterror weapon, remember that!
Rio:
Professor, how was smallpox treated at that time?
Professor:
Quarantine, vaccination, and people burned all infected clothes and bedding. Those
interventions helped the world flatten the epidemic curve. It was thought as an
airborne contagious disease that governments panicked in controlling the spread
of smallpox. Separate wards in hospitals were built solely for the terminal
virus, killing an estimated 300 million people.
Stockholm:
Oh, that’s a lot! I pray that COVID pandemic will not kill that much,
professor.
Nairobi:
Ladies, did you know that the term vaccine (vaccinum) was derived from the
Latin word for cow (vacca)? That’s how it reflects the origins of smallpox
vaccination. Is it right professor? (amused pleasantly as the crowd gives her a
round of applause with her trivial opinion).
Professor:
You’re right, senora Nairobi! (he returns the sugary smile at her).
But
that’s a misnomer for sure. It’s because the vaccine used to prevent smallpox was
likely a horsepox, not cowpox.
Dr.
Edward Jenner observed that milkmaids who had gotten cowpox did not show any
symptoms of smallpox after variolation or inoculation.
Actually,
he infected a young boy with cowpox, but later when he injected the child with
the deadly smallpox virus, he did not get sick. It was an accidental mistake
that cured the boy. That beautiful mistake cured everybody with smallpox around
the world!
Nairobi:
Our son would be a genius, professor! If only… (she recalls her offer to him of
an artificial insemination while Inspector Raquel smiles at them and sobs in
sorrow of Nairobi’s loss).
Manila:
Eh professor, how much time did they discover the vaccine for smallpox?
Palermo:
The history of smallpox extends into pre-history. The disease likely emerged in
human populations about 10,000 BC. The earliest credible evidence of smallpox
is found in the Egyptian mummies of people who died some 3000 years ago
(looking at Helsinki, trying to impress him).
Professor:
That’s right, Palermo…and (trying to expound the facts when Berlin rebuts).
Berlin:
Yes, smallpox has existed for at least 3,000 years and was one of the world's
most feared diseases until it was eradicated by a collaborative global
vaccination programme. The last known natural case was in Somalia in 1977.
Moscow:
But China and India practiced smallpox inoculation even before the discovery of
vaccination?
Professor:
Very well, Moscow. That’s a method for
the prevention of smallpox by deliberate introduction of material from smallpox
pustules into the skin. This generally produced a less severe infection than
naturally-acquired smallpox, but still induced immunity to it.
Just
like in COVID now, countries use various kinds of method. States that
experienced relative diseases on SARS, MIERS-COV, and Ebola virus are better
off in their medical practice and herd immunity compared with nations that have
less exposure on the coronavirus. It’s a novel disease. Still, we’re figuring
it out whether or not it’s a natural virus…
Manila:
Professor, you didn’t answer me. How much time before Dr. Jenner discovered the
vaccine?
In
the Philippines, the government is giving away 50 million pesos as a bounty to
the discoverer of the vaccine - they got virgin coconut oil and other
alternative medicine. Other countries are doing the same thing, giving away
prizes to bright ideas. We don’t need to rob banks anymore if we happen to discover
the vaccine.
Professor:
There’s no vaccine yet for COVID, Manila! (his voice sounds in anguish).
Dr.
Jenner’s method underwent medical and technological changes over the next 200
years, and eventually resulted in the eradication of smallpox.
Everyone’s
racing for the vaccine. This isn’t about the Nobel Peace Prize for science and
medicine. Scientists and physicians need different stages of clinical trial to
do that. The experiment has to undergo phases of test from small, to medium to
large clinical testing. Once approved then the drug gets certified to be used
by everyone. It should be feasible and mass produced to kill enough the
coronavirus.
It
took the world two centuries before the smallpox disease was naturally
eradicated through a vaccine!
If
our generation won’t survive the plague, perhaps the next generation will
outlive it. We see herd immunity with rising recoveries. That’s good! Scientific
data would show us that with strict quarantine and lockdown, we flatten and
squash the virus, though the contagion keeps on mutating.
Just
like in a flu that can be healed but can’t be cured! Recurring as we see it. There's
no cure for the flu, but there are available natural ways to ease the symptoms.
It can’t because there are drugs that inhibit one of the enzymes that the virus
uses to get into and out of cells.
Right
now, there are potential post-infection therapies for COVID-19-20. These are favipiravir, lopinavir, hydroxychoroquine
or chloroquine. All are in final
stage of human testing before it reaches the fourth phase of manufacturing!
Although there are also individual or combined drugs such as lopinavir-ritonavir combined, lopinavir-ritonavir combined with interferon-beta, remdesivir, and hydroxychloroquine
done in separate trials.
We’re
running out of time ladies and gents! This quest for vaccine can become our
exit strategy. Making sure that the vaccine is safe by undergoing rigorous
testing that should result to harmless consequences. It takes 10 years to do
clinical trials for a vaccine but scientists are racing to discover it for
months, unless hundreds of millions of people will die if we don’t do something
now! It took two centuries to perfect smallpox vaccine.
***
(Outdoor) Denver and
Manila arrive in Mumbai in spite of a national lockdown around India, the
largest sub-continent nation to do so. Inside one of the largest pharmaceutical
companies in the world.
Manila:
Hydroxychloroquine, they say this anti-malarial drugs is a game-changer drug in the fight
against coronavirus. The miracle drug? By the way, how can we convince India to make a surplus
when the rest of the world is still suffering from the pandemic?
Denver:
Let’s do what professor has told us to do. Just prepare billions of Indian
rupees! I trust your negotiation skills, Manila!
Professor:
Denver, do you hear me? (He’s calling them from the satellite network).
Inspector
Sierra is arriving shortly to help you negotiate and get the drugs manufactured!
Do you copy?
TO
BE CONTINUED>>>